Wheaton College Norton, Massachusetts
Wheaton College


Christopher Kalberg

Christopher Kalberg

Associate Professor of Chemistry

Ph.D. Duke University 1998
B.S. Loras College 1993

Research Interests

My research program is in the general area of synthesis of small organic molecules that are of biological or pharmaceutical interest. Recent investigations have focused on the application of Green Chemistry Principles to the production of chiral, single stereoisomer amino acids and hydroxy acids. Specifically, we have been using commercially available transition metal catalysts in an aqueous reaction mixture to produce such chiral small molecules.

Teaching Interests

I have taught courses at all levels of the Chemistry Department curriculum from introductory courses such as general chemistry all the way through advanced inorganic, advanced organic and senior seminar which are courses for senior chemistry majors. In the last several years however, my main teaching focus has been on the two semester organic chemistry sequence that is typically taken during the sophomore year and on the inorganic chemistry course often taken by juniors.


C.S. Kalberg "Chapter 9: Building Flexibility for the Undergraduate Chemistry Laboratory" in Innovations and Renovations: Designing the Teaching Laboratory, L. A. O'Connell, ed., ACS Symposium Series 1146, Oxford University Press, 2013.

K.L. Boyle, E.B. Lipsky, C.S. Kalberg "Asymmetric Hydrogenation of Methyl α-benzamido Cinnamate in Ionic Liquid Solvent" Tetrahedron Lett. 2006, 1311-1313.

C.S. Kalberg, P.J. Ogren "An Inexpensive Convenient Press for KBr and CsI Pelets in Infrared Studies" J. Chem. Educ. 2000, 77, 391.

M.J. Burk, C.S. Kalberg, A. Pizzano "Rh-DuPHOS-Catalyzed Enantioselective Hydrogenation of Enol Esters. Application to the Synthesis of Highly Enantioenriched α-Hydroxy Esters and 1,2-Diols" J. Am. Chem. Soc. 1998, 120, 4345.

M.J. Burk, M.F. Gross, T.G.P. Harper, C.S. Kalberg, J.R. Lee, J.P. Martinez "Asymmetric Catalytic Routes to Chiral Building Blocks of Medicinal Interest" Pure and Applied Chem. 1996, 68, 33.

M.J. Burk, T.G.P. Harper, C.S. Kalberg "Highly Enantioselective Hydrogenation of β-Keto Esters Under Mild Conditions" J. Am. Chem. Soc. 1995, 117, 4423.

M.J. Burk, T.G.P. Harper, J.R. Lee, C.S. Kalberg "Efficient Rhodium-Catalyzed Hydrogenation of Aldehydes and Ketones" Tetrahedron Lett. 1994, 35, 4963.


*C.M. Chapman, C.S.Kalberg "Asymmetric Hydrogenation of α-Benzamido Acrylate Esters in Water" 239th American Chemical Society National Meeting, San Francisco, CA March 21-25, 2010.

*C.S. Kalberg, K.L. Boyle, E.B. Lipsky "Asymmetric Hydrogenation of α-Enamide Esters in Ionic Liquid Solvent" 231st American Chamical Society National Meeting, Atlanta, GA March 26-30, 2006.

Student Projects

I currently have one senior students working on an independent research project. Nick Fredette '15 is investigating the green asymmetric synthesis of heteroatom (N and S) substituted amino acids.