Wheaton College Norton, Massachusetts
Wheaton College


Christopher Kalberg

Christopher Kalberg

Associate Professor of Chemistry

Ph.D. Duke University 1998
B.S. Loras College 1993

Research Interests

My research program is in the general area of synthesis of small organic molecules that are of biological or pharmaceutical interest. Recently, I have been investigating the application of Green Chemistry Principles to the production of chiral single stereoisomer amino acids and hydroxy acids. Specifically, we have been using commercially available transition metal catalysts in an aqueous reaction mixture to produce such molecules.

Teaching Interests

I have taught courses at all levels of the Chemistry Department curriculum from introductory courses such as general chemistry all the way through advanced inorganic and advanced organic which are courses for senior chemistry majors. In the last several years however, my main teaching focus has been on the two semester organic chemistry sequence that is typically taken during the sophomore year. During the spring semester of 2013, I am teaching the Chem 400 Seminar course and I will participate in the Organic Chemistry I laboratory.


K.L. Boyle, E.B. Lipsky, C.S. Kalberg "Asymmetric Hydrogenation of Methyl α-benzamido Cinnamate in Ionic Liquid Solvent" Tetrahedron Lett. 2006, 1311-1313.

C.S. Kalberg, P.J. Ogren "An Inexpensive Convenient Press for KBr and CsI Pelets in Infrared Studies" J. Chem. Educ. 2000, 77, 391.

M.J. Burk, C.S. Kalberg, A. Pizzano "Rh-DuPHOS-Catalyzed Enantioselective Hydrogenation of Enol Esters. Application to the Synthesis of Highly Enantioenriched α-Hydroxy Esters and 1,2-Diols" J. Am. Chem. Soc. 1998, 120, 4345.

M.J. Burk, M.F. Gross, T.G.P. Harper, C.S. Kalberg, J.R. Lee, J.P. Martinez "Asymmetric Catalytic Routes to Chiral Building Blocks of Medicinal Interest" Pure and Applied Chem. 1996, 68, 33.

M.J. Burk, T.G.P. Harper, C.S. Kalberg "Highly Enantioselective Hydrogenation of β-Keto Esters Under Mild Conditions" J. Am. Chem. Soc. 1995, 117, 4423.

M.J. Burk, T.G.P. Harper, J.R. Lee, C.S. Kalberg "Efficient Rhodium-Catalyzed Hydrogenation of Aldehydes and Ketones" Tetrahedron Lett. 1994, 35, 4963.


*C.M. Chapman, C.S.Kalberg "Asymmetric Hydrogenation of α-Benzamido Acrylate Esters in Water" 239th American Chemical Society National Meeting, San Francisco, CA March 21-25, 2010.

*C.S. Kalberg, K.L. Boyle, E.B. Lipsky "Asymmetric Hydrogenation of α-Enamide Esters in Ionic Liquid Solvent" 231st American Chamical Society National Meeting, Atlanta, GA March 26-30, 2006.

Student Projects

I currently have two senior students working of research projects. Amy Moriera '12 is continuing the work begun by Chiara Chapman '10 investigating the use of DuPHOS catalysts to make single stereoisomer tyrosine analogs using water as the solvent for the reaction. Zach Dunn '12 is attempting to carry out a similar type of reaction to make protected α-hydroxy acids which are found in many marine natural products.